Articles

Lab members are italicized, * indicates equal contribution

Whitehouse S, Chen PL, Greenshields AL, Nightingale M, Hoskin DW, Bedard K. Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties. (2016) Phytomedicine 23(12):1494-1503. doi: 10.1016/j.phymed.2016.08.011. Epub 2016 Aug 31.

Gaston D*, Hansford S*, Oliveira C, Nightingale M, Pinheiro P, Macgillivray C, Kaurah P, Rideout AL, Steele P, Soares G, Huang WY, Whitehouse S, Blowers S, LeBlanc MA, Jiang H, Greer W, Samuels ME, Orr A, Fernandez CV, Majewski J, Ludman M, Dyack S, Penney LS, McMaster CR, Huntsman D, Bedard K Germline Mutations in MAP3K6 Are Associated with Familial Gastric Cancer (2014) PLOS Genetics doi: 10.1371/journal.pgen.1004669

Bentley VL, Veinotte CJ, Corkery DP, Pinder JB, LeBlanc MA, Bedard K, Weng AP, Berman JN, Dellaire G Focused chemical genomics using zebrafish xenotransplantation as a preclinical therapeutic platform for T-cell acute lymphoblastic leukemia (2014) Haematologica pii: haematol.2014.110742. [Epub ahead of print]

Robitaille JM, Gillett RM, LeBlanc MA, Gaston D, Nightingale M, Mackley MP, Parkash S, Hathaway J, Thomas A, Ells A, Traboulsi EI, Héon E, Roy M, Shalev S, Fernandez CV, MacGillivray C, Wallace K, Fahiminiya S, Majewski J, McMaster CR, Bedard K Phenotypic Overlap Between Familial Exudative Vitreoretinopathy and Microcephaly, Lymphedema, and Chorioretinal Dysplasia Caused by KIF11 Mutations (2014) JAMA Ophthalmology Published online August 14, 2014. doi:10.1001/jamaophthalmol.2014.2814.

LeBlanc MA, Penney LS, Gaston D, Shi Y, Aberg E, Nightingale M, Jiang H, Gillett RM, Fahiminiya S, Macgillivray C, Wood EP, Acott PD, Khan MN, Samuels ME, Majewski J, Orr A, McMaster CR, Bedard K A novel rearrangement of occludin causes brain calcification and renal dysfunction (2013) Human Genetics 132: 1223-1234

Bogdanik L, Sleigh J, Tian C, Samuels ME, Bedard K, Seburn K, and Burgess RW Loss of Lrsam1, a Charcot-Marie-Tooth disease-associated E3 ubiquitin ligase, sensitizes peripheral axons to degeneration in mice (2013) Disease Models and Mechanisms 6: 780-92

Copeland E, Renault N, Renault M, Dyack S, Bulman DE, Bedard K, Otley A, Magee F, Acott P and Greer WL. A Novel Splice-Site Mutation in ATP8B1 Results in Atypical Progressive Familial Intrahepatic Cholestasis Type 1 (2013) Journal of Gastroenterology and Hepatology 28:560-564

Bedard K, Jaquet V (2012) Cell-free Screening for NOX Inhibitors Chem Biol 2012 19, 664-5

Attar H; Bedard K; Migliavacca E; Gagnebin M; Dupré Y; Descombes P; Borel C; Deutsch S; Prokisch H; Meitinger T; Mehta D; Wichmann EH; Delabar JM; Dermitzakis ED; Krause KH; Antonarakis SE (2012) Extensive natural variation for cellular hydrogen peroxide release is genetically controlled PLoS One 7:e43566

Bedard K, Jaquet V and Krause KH (2012) Nox5: from basic biology to signaling and disease Free Radical Biology and Medicine 52: 725-34

Jaquet V, Leidal K, Perozzo R, Plastre O, Fioraso-Cartier L, Diebold B, Scapozza L, Nauseef WM, Krause KH* and Bedard K* (2011) NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action British Journal of Pharmacology, 164: 507-520

Guernsey DL, Jiang H, Bedard K, Evans SC, Ferguson M, Matsuoka M, Macgillivray C, Nightingale M, Perry S, Rideout AL, Orr A, Ludman M,Skidmore DL, Benstead T, Samuels ME (2010) Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth Syndrome PLoS Genet, 6, e1001081

Kraus A, Jung J, Groenendyk J, Bedard K, Krause KH, Dubois-Dauphin M, Baldwin TA, Agellon LB, Dyke J, Gosgnach S, Rosenbaum E, Korngut L, Colley NJ, Zochodne D, Todd K, and Michalak M (2010) Calnexin Deficiency Leads to Dysmyelination   Journal of Biological Chemistry, 285, 18928-38

Li B, Bedard K, Sorce S, Dubois-Dauphin M, and Krause KH (2009) NOX4-dependent ROS generation in a human microglial cell line Journal of Innate Immunity   1, 570-581

Jaquet V and Bedard K (2009) Genetic Mapping – the path of discovery for novel functions of the NOX NADPH oxidases Journal of Leukocyte Biology 86, 461-3

Bedard K, Attar H, Bonnefont B, Jaquet V, Borel C, Plastre O, Stasia MJ, Anotonarakis SE, Krause KH (2009) Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation Human Mutation 30, 1123-1233

Basset O, Deffert C, Foti M, Bedard K, Jaquet V, Ogier-Denis E and Krause KH (2009) NADPH Oxidase 1 Deficiency alters caveolin phosphorylation and angiotensin II receptor localization in vascular smooth muscle Antioxidants and Redox Signaling 11, 2371-2384

Guernsey DL, Jiang H, Evans SC, Ferguson M, Matsuoka M, Nightingale M, Rideout A, Provost S, Bedard K, Orr A, Dubé MP, Ludman M, Samuels ME (2009) Mutation in pyrroline 5-carboxylate reductase gene 1 in families with cutis laxa type 2 American Journal of Human Genetics 85, 120-129

Krause KH, Bedard K (2008) NOX enzymes in immuno-inflammatory pathologies Seminars in Immunopathol 30, 193-194

Coe H, Bedard K, Groenendyk J, Jung J, Michalak M (2008) Endoplasmic reticulum stress in the absence of calnexin Cell Stress Chaperones13, 497-507

Bedard K, Lardy B, Krause KH (2007) NOX Family NADPH Oxidases: Not Just in Mammals Biochimie 89, 1107-1112

Bedard K, Krause KH (2007) The NOX family of ROS generating NADPH oxidases: physiology and pathophysiology Physiological Reviews, 87, 245-313

Serrander L, Jaquet V, Bedard K, Plastre O, Hartley O, Arnaudeau S, Demaurex N, Schlegel W, Krause KH (2007) NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation Biochimie 89, 1159-1167

Serrander L, Cartier L, Bedard K, Banfi B, Lardy B, Plastre O, Sienkiewicz A, Fórró L, Schlegel W, Krause KH (2007) NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation Biochemical Journal 406, 105-114

Bedard K, Eva Szabo, Michalak M, Opas M (2005) Cellular Functions of ER Chaperones Calreticulin, Calnexin and Erp57 International Review of Cytology – A Survey of Cell Biology, 245, 91-121

Ryan P, Bedard K, Breining T, Cribb A (2005) Disruption of the Endoplasmic Reticulum by Cytotoxins in LLC-PK1 Cells Toxicology Letters, 159, 154-163

Bedard K, MacDonald N, Collins J and Cribb A (2004) Cytoprotection following endoplasmic reticulum stress protein induction in continuous cell lines Pharmacology and Toxicology, 94: 124-131

Bedard K, Fuentealba C and Cribb A (2000) The Long Evans Cinnamon (LEC) rat develops hepatocellular damage in the absence of antimicrosomal antibodies Toxicology, 146: 101-109

Bedard K, Smith SR and Cribb AE (2000) Sequential assessment of an anti-drug antibody response in a patient with a systemic delayed onset sulfonamide hypersensitivity reaction The British Journal of Dermatology, 142: 253-258