Mat Nightingale

Research Assistant

Mat 3_crop

Biography

I studied Biological Sciences at the University of Abertay, Dundee, Scotland, graduating in 1997. I then began working for Eurogentec, a commercial DNA sequencing facility based in my hometown of Southampton, England for 7 years.

I spent 2 years in the research laboratory of Dr. Fiona Ross at Salisbury District Hospital (England) studying Multiple Myeloma, and investigating the critical importance of detecting chromosome 13 and chromosome 16q deletions from bone marrow samples and it’s effect on patient prognosis. During this time I also created & ran the UK Multiple Myeloma nucleic acid bank. I emigrated from England to Canada in 2007 with my family to work with Dr Duane Guernsey as part of the AMGGI team based at Dalhousie University. I’m currently a part of Dr. Karen Bedard’s lab, working on a number of projects including renal failure, ARVC, congenital alacrima, gastric cancer, essential thrombocythemia, nemaline myopathy and progeria.

When not in the lab I enjoy spending time with my family, astrophotography and 3D printing.

Publications

Whitehouse S, Chen PL, Greenshields AL, Nightingale M, Hoskin DW, Bedard K. Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties. (2016) Phytomedicine 23(12):1494-1503. doi: 10.1016/j.phymed.2016.08.011. Epub 2016 Aug 31.

Gaston D*, Hansford S*, Oliveira C, Nightingale M, Pinheiro P, Macgillivray C, Kaurah P, Rideout AL, Steele P, Soares G, Huang WY, Whitehouse S, Blowers S, LeBlanc MA, Jiang H, Greer W, Samuels ME, Orr A, Fernandez CV, Majewski J, Ludman M, Dyack S, Penney LS, McMaster CR, Huntsman D, Bedard K Germline Mutations in MAP3K6 Are Associated with Familial Gastric Cancer (2014) PLOS Genetics doi: 10.1371/journal.pgen.1004669

Robitaille JM, Gillett RM, LeBlanc MA, Gaston D, Nightingale M, Mackley MP, Parkash S, Hathaway J, Thomas A, Ells A, Traboulsi EI, Héon E, Roy M, Shalev S, Fernandez CV, MacGillivray C, Wallace K, Fahiminiya S, Majewski J, McMaster CR, Bedard K Phenotypic Overlap Between Familial Exudative Vitreoretinopathy and Microcephaly, Lymphedema, and Chorioretinal Dysplasia Caused by KIF11 Mutations (2014) JAMA Ophthalmology Published online August 14, 2014. doi:10.1001/jamaophthalmol.2014.2814.

LeBlanc MA, Penney LS, Gaston D, Shi Y, Aberg E, Nightingale M, Jiang H, Gillett RM, Fahiminiya S, Macgillivray C, Wood EP, Acott PD, Khan MN, Samuels ME, Majewski J, Orr A, McMaster CR, Bedard K. A novel rearrangement of occludin causes brain calcification and renal dysfunction. Hum Genet. 2013 Nov;132(11):1223-34. doi: 10.1007/s00439-013-1327-y. Epub 2013 Jun 21. PubMed PMID: 23793442.

Orr A, Dubé MP, Zenteno JC, Jiang H, Asselin G, Evans SC, Caqueret A, Lakosha H, Letourneau L, Marcadier J, Matsuoka M, Macgillivray C, Nightingale M, Papillon-Cavanagh S, Perry S, Provost S, Ludman M, Guernsey DL, Samuels ME. Mutations in a novel serine protease PRSS56 in families with nanophthalmos. Mol Vis. 2011;17:1850-61. Epub 2011 Jul 12. PubMed PMID: 21850159; PubMed Central PMCID: PMC3137557.

Guernsey DL, Matsuoka M, Jiang H, Evans S, Macgillivray C, Nightingale M, Perry S, Ferguson M, LeBlanc M, Paquette J, Patry L, Rideout AL, Thomas A, Orr A, McMaster CR, Michaud JL, Deal C, Langlois S, Superneau DW, Parkash S, Ludman M, Skidmore DL, Samuels ME. Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. Nat Genet. 2011 Feb 27;43(4):360-4. doi: 10.1038/ng.777. PubMed PMID: 21358631.

Guernsey DL, Jiang H, Bedard K, Evans SC, Ferguson M, Matsuoka M, Macgillivray C, Nightingale M, Perry S, Rideout AL, Orr A, Ludman M, Skidmore DL, Benstead T, Samuels ME. Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease. PLoS Genet. 2010 Aug 26;6(8). doi:pii: e1001081. 10.1371/journal.pgen.1001081. PubMed PMID: 20865121; PubMed Central PMCID: PMC2928813.

Guernsey DL, Jiang H, Hussin J, Arnold M, Bouyakdan K, Perry S, Babineau-Sturk T, Beis J, Dumas N, Evans SC, Ferguson M, Matsuoka M, Macgillivray
C, Nightingale M, Patry L, Rideout AL, Thomas A, Orr A, Hoffmann I, Michaud JL, Awadalla P, Meek DC, Ludman M, Samuels ME. Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Am J Hum Genet. 2010 Jul 9;87(1):40-51. doi: 10.1016/j.ajhg.2010.06.003. PubMed PMID: 20598275; PubMed Central PMCID: PMC2896783.

Guernsey DL, Dubé MP, Jiang H, Asselin G, Blowers S, Evans S, Ferguson M, Macgillivray C, Matsuoka M, Nightingale M, Rideout A, Delatycki M, Orr A, Ludman M, Dooley J, Riddell C, Samuels ME. Novel mutations in the sacsin gene in ataxia patients from Maritime Canada. J Neurol Sci. 2010 Jan 15;288(1-2):79-87. doi: 10.1016/j.jns.2009.09.034. Epub 2009 Nov 4. PubMed PMID: 19892370.

Guernsey DL, Jiang H, Evans SC, Ferguson M, Matsuoka M, Nightingale M, Rideout AL, Provost S, Bedard K, Orr A, Dubé MP, Ludman M, Samuels ME. Mutation in pyrroline-5-carboxylate reductase 1 gene in families with cutis laxa type 2. Am J Hum Genet. 2009 Jul;85(1):120-9. doi: 10.1016/j.ajhg.2009.06.008. Epub 2009 Jul 2. PubMed PMID: 19576563; PubMed Central PMCID: PMC2706970.

Guernsey DL, Jiang H, Campagna DR, Evans SC, Ferguson M, Kellogg MD, Lachance M, Matsuoka M, Nightingale M, Rideout A, Saint-Amant L, Schmidt PJ, Orr A, Bottomley SS, Fleming MD, Ludman M, Dyack S, Fernandez CV, Samuels ME. Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Nat Genet. 2009 Jun;41(6):651-3. doi:
10.1038/ng.359. Epub 2009 May 3. PubMed PMID: 19412178.

Jenner MW, Leone PE, Walker BA, Ross FM, Johnson DC, Gonzalez D, Chiecchio L, Dachs Cabanas E, Dagrada GP, Nightingale M, Protheroe RK, Stockley D, Else M, Dickens NJ, Cross NC, Davies FE, Morgan GJ. Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma. Blood. 2007 Nov 1;110(9):3291-300. Epub 2007 Jul 3. PubMed PMID: 17609426.

L Chiecchio, GP Dagrada, RKM Protheroe, PE Leone, M Nightingale, DM Stockley, BA Walker, MW Jenner, FE Davies, GJ Morgan, NCP Cross, FM Ross. Chromosome 1 abnormalities in myeloma and MGUS. Haematologica. 2007 92(6):103

FM Ross, L Chiecchio, RKM Protheroe, GP Dagrada, DM Stockley, M Nightingale, NCP Cross, CJ Harrison, KH Orchard. Stable asymptomatic myeloma and MGUS in the presence of T (4; 14). Haematologica. 2007 92(Supplement 1):330-331

AC Rawstron, L Chiecchio, R de Tute, GP Dagrada, RKM Protheroe, M Nightingale, D Stockley, JAC Child, FE Davies, GJ Morgan, RG Owen, F Ross. Plasma cell immunophenotype is highly predictive of the level of chromosomal abnormalities in patients with MGUS. Haematologica. 2007 92(6):198

FM Ross, L Chiecchio, GP Dagrada, RKM Protheroe, M Nightingale, DM Stockley, NCP Cross. IGH rearrangements in plasma cell dyscrasias. Haematologica. 2007 92(6, Supplement 2): 102-103

Matthew W Jenner, Paola E Leone, Brian A Walker, Fiona M Ross, David C Johnson, David Gonzalez, Laura Chiecchio, Elisabet Dachs Cabanas, Gian Paolo Dagrada, Mathew Nightingale, Rebecca KM Protheroe, David Stockley, Monica Else, Nicholas J Dickens, Nicholas CP Cross, Faith E Davies, Gareth J Morgan, Gareth Morgan, Surrey SM Sutton. Blood First Edition Paper, prepublished online July 3, 2007; DOI 10.1182/blood-2007-02-075069

MW Jenner, PE Leone, BA Walker, DC Johnson, L Chiecchio, E Dachs Cabanas, GP Dagrada, M Nightingale, RKM Protheroe, D Stockley, M Else, NJ Dickens, FM Ross, NCP Cross, FE Davies, GJ Morgan. Deletion of 16q identified by FISH is an independent adverse prognostic marker in multiple myeloma. British Journal of Haematology. 2007 137(Supplemental 1):1

Matthew W Jenner, Paola E Leone, Brian A Walker, David C Johnson, Laura Chiecchio, Elisabet Dachs Cabanas, Gian Paolo Dagrada, Mathew Nightingale, Rebecca KM Protheroe, David Stockley, Monica Else, Fiona M Ross, Nicholas CP Cross, Faith E Davies, Gareth J Morgan. Abnormalities of 16q in multiple myeloma are associated with poor prognosis: 500K gene mapping and expression correlations identify two potential tumor suppressor genes, WWOX and CYLD. Blood. 2006 Nov 108(11):37A

Chiecchio L, Protheroe RK, Ibrahim AH, Cheung KL, Rudduck C, Dagrada GP, Cabanas ED, Parker T, Nightingale M, Wechalekar A, Orchard KH, Harrison CJ, Cross NC, Morgan GJ, Ross FM. Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma. Leukemia. 2006 Sep;20(9):1610-7. Epub 2006 Jul 6. PubMed PMID: 16826223.

Laura Chiecchio, Rebecca KM Protheroe, Tim Parker, Christina Rudduck, Kan Luk Cheung, Gianpaolo Dagrada, Ashutosh Wechalekar, Mathew Nightingale, Christine J Harrison, Nicholas CP Cross, Fiona M Ross. Critical importance of conventional cytogenetics in detecting prognostically significant chromosome 13 deletions in myeloma. Blood. 2005 Nov 106(11):443A

L Chiecchio, RKM Protheroe, T Parker, C Rudduck, KL Cheung, G Dagrada, A Wechalekar, M Nightingale, CJ Harrison, NCP Cross. Critical Importance of Conventional Cytogenetics in Detecting Prognostically Significant Chromosome 13 Deletions in Myeloma.(Poster# 702-I). Blood. 2005 106(11):1544